Adenomyosis is an enigmatic uterine condition, defined as the presence of endometrial glands and stroma within the myometrium. It affects many women of reproductive age and is a contributing factor to pelvic pain, severe menstrual cramps, heavy bleeding and infertility. Current treatment options for adenomyosis are mainly pharmacological and surgical. Pharmacological treatment is mainly associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hormonal drugs. However, these drugs may cause adverse effects when used for a long-term treatment of adenomyosis such as nausea, vomiting, gastrointestinal reactions, abnormal liver and kidney function, gastric ulcers and thrombosis. Although adenomyosis lesions can be surgically removed affecting uterine functionality, the disease has a high recurrence rate after surgical resection. Therefore, there is an urgent need to develop alternative or additional therapies for the treatment of adenomyosis. Polyphenols reduce the number and size of adenomyosis foci through autophagy, mitophagy and apoptosis elements that are not available in existing preparations that relieve pain and generally symptoms and discomfort that return after discontinuation of treatment. The actions are antiproliferative, antiangiogenic, anti-

inflammatory and proapoptotic. It does not present the side effects of hormonal preparations that stop menstruation, and may cause osteoporosis.