Endophol was created from natural products for the management of women who experience endometriosis, dysmenorrhea(painful menstrualow) and dyspareunia (painful intercourse) According to the latest data, the causative factor of  ndometriosis can be considered chronic inammation caused by increased levels of oxidative stress. Targeting oxidative stress appears to be a promising strategy for both limiting the
progression of endometrial damage and alleviating the symptoms, chronic pain and subfertility associated with endometriosis.(1,2,12)
Endophol was created from natural products to manage women experiencing endometriosis, dysmenorrhea (painfulmenstruation) and dyspareunia (painful intercourse). Was designed especially for women who want to take natural
(herbal) products (with intense antioxidant activity) or in addition to and in combination with classical pharmacotherapy. Their purpose is to complement the daily diet and in no case to replace it. Oxidative stress management is considered a promising new strategy to manage, limit the progression of endometriosis and alleviate chronic pain

Endometriosis / Causes, frequency and symptoms

Endometriosis is considered a pathological benign disorder /disease where endometrial glands and stroma are found outside the endometrial cavity, in the  eritoneum, ovaries, fallopian tubes and elsewhere. It is formed mainly by menstrualow blood that returns through the fallopian tubes and implants in the peritoneal cavity, by metaplasia of cells from one type to another, by stem cells that are transported with the blood or lymph vessels to various parts of the body causing a local reaction and inammation. (1,2,12)

Endometriosis occurs in 10% of women of reproductive age and 30%-40% of subfertile women causing painful menstruation, chronic pelvic pain, pain during or after intercourse, painful bowel movements, painful urination, abdominal bloating, nausea, fatigue, depression or anxiety, thus affecting the quality of life (WHO 31 March 2021). (3 )

It also creates infertility, due to the peritoneal inammatory reaction affecting the eggs and sperm.

Dysmenorrhea and pelvic pain in adolescent girls

Adolescent Dysmenorrhea can be primary or secondary Primary dysmenorrhea is associated with anovulatory cycles and is due to increased prostaglandin levels usually occurs 6-12 months after menstruation Secondary dysmenorrhea usually occurs 12 months after menstruation and may be due to endometriosis, adenomyosis and occlusive abnormalities. Adolescent dysmenorrhoea is the most common reason for
missing school activities. 20-40% report missing classes due to dysmenorrhea and 40% report a negative effect on school performance and concentration.(4)

Endometriosis and IVF 

In IVF, it affects the quality of eggs and embryos due to the oxidative stress created in the environment of the egg, thus reducing success rates.(5)

Treatment

It can be hormonal, or with non-steroidal anti-inammatory, surgical or even with natural products Natural products have a strong antioxidant, anti-inammatory, anti-angiogenic and anti-apoptotic effect, contributing signi-cantly to the management of endometriosis, dysmenorrhea and dyspareunia. The side effects are minimal compared to the possible side effects of hormonal preparations, such as venous thrombosis and osteoporosis, while non-steroidal anti-inammatory preparations can cause gastrointestinal or renal disturbances.(6) Nutritional supplements should not be used as substitutes for a balanced diet. Do not exceed the recommended daily dose. This product is not intended to prevent, treat or cure human disease