Acne is one of the most commonly diagnosed skin diseases. There are many different types of acne, of which acne vulgaris and rosacea are the two most commonly diagnosed types. Acne is mainly inflammatory, very often complicated by infection. Polyphenolic compounds, due to their significant diversity and high biological activity, have found a special place in studies on their use in the treatment of acne A particularly large number of studies have been conducted in the last 5 years, which have shown the high effectiveness of many polyphenolic compounds in eliminating the bacteria responsible for the development and progression of acne lesions, also taking into account antibiotic-resistant strains. These are mainly in vitro studies, and among the tested polyphenolic compounds, are quercetin, and resveratrol. Resveratrol due to its potent antioxidant, antibacterial, antiviral, antisebaceous and anti-inflammatory effects. Resveratrol appears to be one of the most promising natural agents against acne. However, it is important to note that there are many other phenolic compounds such as indicaxanthin, taurine, and curcumin that also demonstrate efficacy in combating acne. Plant polyphenols can reduce inflammation by reducing the production of cytokines IL-1, IL-6 and IL-8, hyperkeratinization and sebum release. reduce ROS production, which is an important factor in limiting the development of acne lesions.
Bibliography
Plant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review.Wojciech Koch et.al. Molecules.2024